There’s no doubt that the development of CRISPR/Cas, an immune surveillance system in bacteria and archaea, into a precise genome editing tool is one of the most significant scientific discoveries of this century. CRISPR/Cas is flexible, easy-to-use, fast and incredibly efficient. New, CRISPR based effector technologies are rapidly expanding the versatility of our genome editing toolbox.

  • Using genetic muscle disorders as disease model systems, we’re developing new gene editing technologies with the hope that they can one day contribute in the treatment of these disorders.
  • We’ve developed a unique transduction technology (iTOP) for the rapid and highly efficient delivery of recombinant CRISPR/Cas ribonucleoprotein complex (RNP) into therapeutically relevant target cells.
Genome Editing

We’re developing new CRISPR-based effector proteins with protein engineering and in vitro evolution approaches to enhance favorable properties, develop novel functions and expand the versatility of CRISPR/Cas technologies.

SKELETAL MUSCLE

SKELETAL
MUSCLE

MODELS OF EMBRYONIC DEVELOPMENT

MODELS OF EMBRYONIC
DEVELOPMENT